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In contrast, upon addition of exogenous H 2 O 2 , the matrixtargeted Grx1roGFP2 probe exhibited a significantly larger response than the cytosollocalized Grx1roGFP2 (Fig 1D)
If a biological signal stays present for a long time, it may make the receptors it acts on become less responsive
FOXO4-DRI represents a peptide-based senolytic approach that is more targeted than small-molecule senolytics like dasatinib plus quercetin, which affect broader cellular pathways
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